Redefining cardiac safety

Redefining cardiac safety

Cardiotoxicity research from Clements et al. (Toxicol. Sci. (2015) 148 (1): 241-260) containing data from the Maestro MEA platform was featured on the November 2015 cover of Toxicological Sciences.


Click below to learn more about using the Maestro for in vitro, predictive cardiac safety research.
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Photo of the Maestro MEA system by Axion Biosystems.

The Maestro

Perform neural and cardiac analysis on an unparalleled scale. The plug-and-play Maestro makes MEA experiments simpler and faster than ever before. Learn More

Neuroscience applications

Neuroscience applications

Maestro users discuss using MEA to create “disease-in-a-dish” models for autism, bipolar disorder and pain

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AxIS 2.1 - new release!

AxIS 2.1 – new release!

Faster processing, plate maps, and integrated analysis tools are just some of the new features added to AxIS. The world’s best MEA acquisition and analysis software is now even better! Learn More

Photo of the miniature environmental chamber by Axion Biosystems.


The ECmini maintains a low flow of pre-mixed gas around the Maestro MEA plate, creating a locally controlled gas environment. The primary application for the ECmini is to maintain carbon dioxide concentrations around MEA cultures, preventing experimental variability caused by pH drift.

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Photo of 96-Well SBS-Compliant Plate by Axion Biosystems.

SLAS-Compliant Plates

Axion’s multiwell plates allow scientists to conduct 12, 48, and 96 simultaneous experiments in an industry-standard microtiter format. By dramatically improving productivity, Axion has made MEA technology practical for applications requiring high-throughput capability such as toxicology, drug screening, and safety pharmacology.

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Photo of the Muse MEA system by Axion Biosystems.

The Muse

The Axion Muse introduces fully integrated stimulation and recording to MEA platforms while dramatically reducing the cost and complexity of MEA research. This efficient, flexible, and compact system is well suited for virtually any laboratory environment. When coupled with Maestro, Muse provides an excellent way to qualify an assay before scaling up to the high-throughput Maestro system.Request Information

Photo of a single-well plate by Axion Biosystems.

Single-Well MEAs

Single-well MEAs are ideally suited for the electrophysiological investigation of both neural and cardiac cultures. Individual microelectrodes are capable of simultaneously monitoring the activity of a dozen or more cells; the arrangement of multiple electrodes into a grid extends the recording range across a 2×2 mm area, providing concurrent access to both single-cell and network-level activity.

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High-throughput electrophysiology for systems-level toxicity testing and drug screening.



Axion’s MEA systems can model complex brain activity and heartbeats in a dish. As a result, toxicity and efficacy can be assessed earlier in the drug development process, and with greater sensitivity and accuracy. These comprehensive system-level evaluations provide an in vitro solution to reducing animal testing, a key objective of the Tox21 and REACH initiatives.

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The Maestro MEA system


Axion’s MEA systems provide a label-free in vitro platform for direct measurement of electrical activity in neurons and cardiomyocytes, while the efficiency and convenience of Axion’s standard MEA plates facilitate use for screening-level applications. The large number of electrodes per well reveals detailed information about systems-level signal propogation.

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“Breakthroughs at Breakfast” – Gladstone Institutes

Join us Wed, September 23 10am at the Gladstone Institutes for an energizing breakfast seminar featuring cutting-edge discoveries made possible with MEA technology. Guest speaker Dr. Daniel Haag will present on incorporating MEA into his research modeling schizophrenia with iPS neurons. Breakfast and validated parking are complimentary! Space is limited, register today!

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CNS World Summit – Philadelphia, PA Sept 9-11

Axion BioSystems is a proud Sponsor of the CNS World Summit being held in Philadelphia, PA Sept 9-11. We’re looking forward to engaging conversations with speakers and attendees during the 9th Neurodegenerative Conditions Research & Development conference. Take a look at our Applications page to see how the Maestro can add immeasurable value to YOUR neuroscience research.

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