Maestro Edge
Maestro Edge™ multiwell microelectrode array (MEA) system is a versatile multimodal MEA and impedance system with 6-, 24-, and 96-well* throughput.
The Maestro Edge noninvasively evaluates cellular function in an easy-to-use in vitro assay. Whether monitoring the intricate, electrical activity of excitable cells (e.g., neurons and cardiomyocytes), or tracking the growth and death of cancer cells, Maestro Edge provides high quality, functional data to accelerate your research.
*96-well only available for impedance.
Key Features
- >> Measure cellular activity label-free and real-time — The Maestro Edge detects key parameters of neural network activity, cardiac functionality, and cell growth, death and attachment.
- >> Precisely control the cells environment — Cells are a product of their environment. Maestro Edge has a smart environmental chamber that finely controls temperature and CO₂ while rejecting electrical noise and mechanical vibrations.
- >> Connect to your network — 384 simultaneous live recordings from your cells with the Neural and Cardiac modules. Now you can understand life’s circuitry label free in real time in 6- or 24-well plates.
- >> Continuous cell monitoring — 96 simultaneous live recordings from your cells with the Impedance module. Track cell proliferation, morphology, and viability in real time.
- >> See your cells — Sometimes you just want to look at your cells under a microscope. Maestro’s CytoView™ patented transparent circuit technology allows cell visualization and assay multiplexing.
- >> Control cellular activity — Recreate specific patterns of cellular activity using electrical stimulation or light pluses (with the Lumos optical stimulation system).
- >> Start your assay with the push of a button — "One button setup,” means temperature and CO₂ levels automatically adjust on plate docking. Plate usage is logged via an integrated plate barcode scanner for convenient experiment tracking.
- >> Monitor the kinetics of your biology on your smartphone — No need to be in lab. With the Impedance module, track changes in cell proliferation, viability, and cell killing over minutes or weeks.
Multiplex your assay: Maestro + Omni
>> Platform cross-compatibility lets you view live-cell imaging alongside real-time, functional data to enhance your analysis
>> Monitor electrode coverage and cell morphology to ensure consistent, quality results
>> Experience no-hassle tracking — the Axion Portal automatically links data via barcode
Overview
Electrical activity can give important context to your research. Detailed functional characterization is critical for understanding disease mechanisms, but many researchers avoid it because the techniques can be laborious. Electrophysiology doesn’t have to be difficult. The Maestro MEA platform makes it easy to perform complex electrophysiological experiments and gain deep insights into the function of cells. But the Maestro Edge isn’t just an MEA system — it also features sensitive impedance-measuring capabilities to monitor the kinetics of cellular growth, death, and signaling in real time.
Since launching our first multiwell plate-based Maestro MEA system more than a decade ago, it has become an indispensable tool in academic, biotech, and pharma labs around the world.
Software
The Maestro Edge platform is available with six software modules: Neural, Cardiac, MEA Viability, MEA Automation, Impedance, and GxP Impedance. Select the software modules to match your assay needs:
Neural – Measure the key parameters of neural network function, including activity (are the neurons functional?), synchrony (are the synapses functional?), and oscillation (is the network functional?).
Cardiac – Record the four key measures of functional cardiac performance, label free and in real time in every well of the multiwell plate: action potential (a.k.a. LEAP assay); field potential; propagation; and contractility.
MEA Viability – Measure cell viability and coverage on MEA plates for a complete structure-function assay.
MEA Automation – Automate Cardiac and Neural MEA assays with this API for interfacing with liquid handling platforms.
Impedance – Track cell proliferation, morphology, and viability label-free and in real-time. Ideal for immuno-oncology, cytotoxicity, virology, cell migration, cell proliferation, GPCR assays, and many more.
GxP Impedance – Achieve FDA 21 CFR Part 11 compliance in GMP/GLP labs with this version of the Impedance Software Module.
Neural Metrics Definitions
The need for powerful neural analysis software does not have to mean complicated software. Download the Neural Metrics document to discover over 50 neural metrics available to you for your data analysis.
Consumables
The Maestro Edge system is compatible with the 24- and 6-well versions of Axion’s MEA plates, and the 96-well impedance assay plate. Select the multiwell plates to match your assay needs:
CytoView MEA™ – The premium Maestro multiwell MEA plate with a transparent well bottom for cell visualization and assay multiplexing. The 24-, and 6-well plate formats are compatible with the Maestro Edge.
BioCircuit MEA™ – Maestro MEA plates with an opaque well bottom delivering high-quality results at the lowest cost per well. The 24-well plate format is compatible with the Maestro Edge.
Lumos MEA™ – Maestro MEA plates designed for use with the Lumos system, featuring a transparent well bottom and light-focusing lid. The 24-well plate format is compatible with the Maestro Edge.
CytoView-Z™ – The Maestro impedance plate with a transparent well bottom for cell visualization and assay multiplexing. Available in a 96-well plate format.
Peripherals
Lumos is a multiwell light stimulation system for optogenetic assays, that pairs with the Maestro Edge. The Maestro Edge platform is compatible with the Lumos 24 optical stimulation system:
Lumos 24™ – For use with Lumos MEA 24 plates. The Lumos 24 system has four LEDs per well (red, orange, green and blue).
Cross-compatible Platforms
The Maestro Edge system has cross-compatibility with:
Omni™ – See whole-plate images of your cultures next to real-time activity measurements. Confirm electrode coverage and culture health with just a few clicks from AxIS Navigator. Compatible with Omni and Omni Pro 12™ systems.
Related Applications
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