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Maestro APEX

The automated solution for your entire Maestro workflow.

PRODUCT OVERVIEW

Maestro APEX is the world’s first dedicated multi-electrode array robotic platform. It addresses the labor-intensive nature of cell based assays by streamlining every stage of your MEA experiment from plate preparation, routine culture maintenance, and running Maestro experiments.

APEX seamlessly integrates a sterile, robotic plate deck with a cell culture incubator increasing walk-away capacity, throughput, and data quality.

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AXION BIOSYSTEMS’ MAESTRO APEX ADVANTAGE

Maestro APEX delivers on the promise of high-throughput MEA assays, not just in a single plate but with a fully integrated system that allows you to make high volume Maestro experiments a way of life. Centered around the Maestro, we created a dedicated MEA workstation that not only frees up your time, but enhances the precision and reliability of each assay with a robotic pipettor.

Through thoughtful innovation, functional activity assays are now easier to perform than ever, with APEX leading the way to facilitate capacity and accuracy alongside Maestro’s high throughput and high definition assays.

FEATURES

All of APEX’s automated functions are seamlessly integrated into a sterile, compact, bench-top workstation.

  • User-configurable 12-position robotic plate deck
  • 44-plate environmentally controlled, automated incubator
  • 4-channel pipettor; accurate liquid transfer from 1uL to 1000uL
  • Sterile plate deck with HEPA filtration and UV light package
  • Two barcode readers
  • Complete AxIS control software integration with Hamilton scheduling software
  • Fully-integrated with Maestro, ECmini, and Axion CO₂ gas mixer
  • Pre-installed programs support 96- and 48-well plates

Maestro APEX product review

Applications

Disease Modeling

Create and explore “disease-in-a-dish” models with superior MEA technology.

  • Read more about Disease Modeling

Drug Discovery

Assess phenotypic behavior at flexible throughputs for both screening and follow-up.

  • Read more about Drug Discovery

Stem Cell Research

Characterize and optimize functional activity of stem cells.

  • Read more about Stem Cell Research

Safety and Toxicity

Understand in vitro toxicity and safety with advanced cell network analysis.

  • Read more about Safety and Toxicity

Resources: Maestro APEX

  • Product literature
  • Peer-reviewed publications
  • Poster presentations

Product literature

Document type Title Authors Requires sign in
Product Brochure MAESTRO APEX™ Automation for every facet of Maestro™ experiments Axion BioSystems
News and Events SPS2018 Poster & Presentation List Axion BioSystems
News and Events SfN2016 poster list Axion BioSystems
Technical Datasheet CytoView MEA 96 - Datasheet Axion BioSystems ✔
News and Events Axion BioSystems Travel Award Axion BioSystems
Technical Datasheet BioCircuit MEA 96 - Datasheet Axion BioSystems ✔
News and Events SOT2017 Poster & Presentations list Axion BioSystems
Application Document CiPA - Application Note Axion BioSystems
Application Document Seizure - Application Note Axion BioSystems
Technical Datasheet AccuSpot Classic MEA 48 - Datasheet Axion BioSystems ✔
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Peer-reviewed publications

Application Title Authors Reference Pub datesort descending
  • Cardiac
  • Safety and Toxicity
The CiPA Microelectrode Array Assay with hSC-Derived Cardiomyocytes: Current Protocol, Future Potential Millard DC, Clements M, Ross JD. Stem Cell-Derived Models in Toxicology Nov 2016
  • Cardiac
  • Safety and Toxicity
International multisite study of human-induced pluripotent stem cell-derived cardiomyocytes for drug proarrhythmic potential assessment Blinova K, Dang Q, Millard D, Smith G, Pierson J, Guo L, Brock M, Lu HR, Kraushaar U, Zeng H, Shi H, Zhang X, Sawada K, Osada T, Kanda Y, Sekino Y, Pang L, Feaster TK, Kettenhofen R, Stockbridge N, Strauss DG, Gintant G. Cell Rep Sep 2018

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Poster presentations

Application Title Authors Forum Pub Datesort descending
  • Cardiac
  • Neural
Maestro APEX™: introducing the first automated system for microelectrode array (MEA) experiments Millard DC, Clements IP, Nicolini AM, Arrowood CA, Parrish C, Ross JD. SLAS 2016
  • Cardiac
  • Safety and Toxicity
CiPA Phase II: Automated cell plating, maintenance, and dosing of hiPSC-derived cardiomyocytes with the Maestro APEX MEA workstation Millard DC, Nicolini AM, Clements M, Parrish C, Ross JD. Safety Pharmacology Society 2016
  • Cardiac
  • Safety and Toxicity
CiPAPhase 2 Study: A case study in development and validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluation Peritore C, Millard DC, Nicolini AM, Chvatal SA, Hayes HB, Clements M, Parrish C, Ross JD. SLAS 2017
  • Cardiac
  • Neural
Multiwell microelectrode array technology for the evaluation of human iPSC-derived neuron and cardiomyocyte product development Peritore C, Nicolini, AM, Hayes HB, Arrowood CA, Clements M, Millard DC, Ross JD. ISSCR 2017

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