The Maestro microelectrode array (MEA) platform is the state-of-the-art in MEA technology. Designed to be easily accessible yet powerful, the Maestro opens new avenues to interrogate cellular function. The Maestro combines real-time, noninvasive electrical measurements with full benchtop environmental control and a multi-well format to measure cellular networks in their native state.
- Flexible throughput in plate formats up to 96 wells accommodates all throughput needs on a single platform
- Easy-to-use hardware and software makes acquiring functional electrophysiological data accessible to everyone – no advanced training required
- Multiwell format facilitates collection of electrophysiological data at throughputs much higher than traditional patch clamp
- Label-free, non-invasive detection keeps cells healthy and intact during recording allowing the same population of cells to be monitored over hours, days, weeks or months.
- Industry-leading electrode count provides 8 or more recording sites in every well for built-in replicates and comprehensive population-based measurements
- On-board environmental control (temperature, CO₂ and humidity) ensures optimal cell health during benchtop recording
- Small footprint means you don’t have to give up valuable bench space for powerful data
Through thoughtful innovation, functional activity assays are now faster and easier to perform than ever.
Examine activity as a culture develops or collect data hours, days, weeks, and even months after a treatment. The label-free, non-invasive nature of MEAs means the same cells may be recorded repeatedly, adding flexibility and an extra dimension to experimental designs.
Learn about bench-top CO₂ control with the ECmini
The Maestro features:
- Industry-leading 768 recording channels
- Temperature, CO2 and humidity control
- Easy to use acquisition and analysis software (AxIS)
- Interchangeable 12-, 48-, or 96-well MEA plates
- Information-rich data collection rate (12.5 kHz)
- Built-in electrical stimulation
- Local technical support and training
The Maestro’s industry-leading 768 electrodes means more recording sites per well. More recording sites means more cells tested and a better representation of the population as a whole. It also means the ability to provide a high number of wells with enough electrodes per well to obtain meaningful data. With 12-, 48-, and an industry-leading 96-well format, the Maestro has an MEA plate with a combination of electrodes and wells suitable for all applications.
|Plate Format||Electrodes Per Well|
Axion never stops innovating. We continue to build on the value of the Maestro product by providing companion devices that expand its capabilities. Streamline your MEA experimental workflow with the Maestro APEX, the first-of-its-kind robotic interface that automates plate preparation, cell culture and MEA analysis. Pairing the Maestro with Lumos, a high-throughput optogenetic stimulation device, provides simultaneous optical control of cellular behavior during network activity recordings.
At the center, AxIS software provides a user-friendly experimental interface for assay creation and analysis.
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||Comparison of the acute inhibitory effects of Tetrodotoxin (TTX) in rat and human neuronal networks for risk assessment purposes||Kasteel EE, Westerink RH.||Toxicol Lett||Mar 2017|
||Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells||Xu X, Tay Y, Sim B, Yoon SI, Huang Y, Ooi J, Utami KH, Ziaei A, Ng B, Radulescu C, Low D, Ng AY, Loh M, Venkatesh B, Ginhoux F, Augustine GJ, Pouladi MA.||Stem Cell Reports||Mar 2017|
||Neuronal hyperactivity causes Na+/H+ exchanger-induced extracellular acidification at active synapses||Chiacchiaretta M, Latifi S, Bramini M, Fadda M, Fassio A, Benfenati F, Cesca F.||J Cell Sci||Mar 2017|
||Comprehensive Translational Assessment of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias||Blinova K, Stohlman J, Vicente J, Chan D, Johannesen L, Hortigon-Vinagre MP, Zamora V, Smith G, Crumb WJ, Pang L, Lyn-Cook B, Ross J, Brock M, Chvatal S, Millard D, Galeotti L, Stockbridge N, Strauss DG.||Toxicol Sci||Jan 2017|
||Comprehensive in vitro cardiac safety assessment using human stem cell technology: Overview of CSAHi HEART initiative||Takasuna K, Asakura K, Araki S, Ando H, Kazusa K, Kitaguchi T, Kunimatsu T, Suzuki S, Miyamoto N.||J Pharmacol Toxicol Methods||Jan 2017|
||Chronic 14-day exposure to insecticides or methylmercury modulates neuronal activity in primary rat cortical cultures||Dingemans MM, Schütte MG, Wiersma DM, de Groot A, van Kleef RG, Wijnolts FM, Westerink RH.||Neurotoxicology||Dec 2016|
||The CiPA Microelectrode Array Assay with hSC-Derived Cardiomyocytes: Current Protocol, Future Potential||Millard DC, Clements M, Ross JD.||Stem Cell-Derived Models in Toxicology||Nov 2016|
||Evaluation of a Microelectrode Array-Based Assay for Neural Network Ontogeny Using Training Set Chemicals||Brown JP, Hall D, Frank CL, Wallace K, Mundy WR, Shafer TJ.||Toxicol Sci||Nov 2016|
||Identification of drug-drug interactions in vitro: a case study evaluating the effects of sofosbuvir and amiodarone on hiPSC-derived cardiomyocytes||Millard DC, Strock CJ, Carlson CB, Aoyama N, Juhasz K, Goetze TA, Stoelzle-Feix S, Becker N, Fertig N, January CT, Anson BD, Ross JD.||Toxicol Sci||Nov 2016|
||Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury||Okubo T, Iwanami A, Kohyama J, Itakura G, Kawabata S, Nishiyama Y, Sugai K, Ozaki M, Iida T, Matsubayashi K, Matsumoto M, Nakamura M, Okano H.||Stem Cell Reports||Oct 2016|
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||In vitro astrocyte model to assess tetramethylenedisulfotetramine (TETS)-induced neuroinflammation||Truong KM, Pessah IN.||Society of Toxicology||2017|
||Evaluating the arrhythmic potential of Vanoxerine in human iPSC derived cardiomyocytes on a multiwell MEA||Strock CJ.||Society of Toxicology||2017|
||Human induced pluripotent stem cell-derived glutamatergic neurons: Evaluating maturation and neurotoxic predictability in the presence or absence of GABAergic neurons and astrocytes using a microelectrode array platform||Bradley JA, Magnin K, Kannemeier C, Swanson B, Strock CJ.||Society of Toxicology||2017|
||Comparison of media effects on cardiac safety testing using induced pluripotent stem cell derived cardiomyocytes||Schocken D, Chan D, Stohlman J, Vicente J, Matta M, Strauss DG, Blinova K.||Society of Toxicology||2017|
||Mutations causing alternating hemiplegia of childhood disrupt normal neural network activity patterns||McSweeney MK, Heinzen E, Boland M, Goldstein D.||Keystone Symposia: Rare and Undiagnosed Diseases||2017|
||Human iPSC-derived neurons for functional assessment of in vitro neurotoxicity and seizure liability||Hess D, Palm T, Fouassier A, Guenther E, Bohlen H.||ISSCR Basel||2017|
||CiPAPhase 2 Study: A case study in development and validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluation||Peritore C, Millard DC, Nicolini AM, Chvatal SA, Hayes HB, Clements M, Parrish C, Ross JD.||SLAS||2017|
||Lumos: A multiwell optical stimulation device for precise control of cell activity||Clements IP, Clements M, Millard DC, Nicolini AM, Arrowood CA, Chvatal SA, Ross JD.||SLAS||2017|
||Leveraging iPSC-derived cortical neurons harboring known epilepsy mutations to advance personalized medicine||Carlson C, McLachlan M, Dominguez E, Meline B, McMahon C, Strouse A, Burke T, DeLaura S, Jones E, Mangan K.||Society for Neuroscience||2016|
||Functional human neurons derived from iPS cells display a range of unique and “exciting” MEA phenotypes||Mangan K, Kannemeier C, Enghofer E, Ma J, DeLaura S, Carlson C.||Society for Neuroscience||2016|
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