Interested to learn how a patient’s unique genetic background can be used to identify improved treatments for chronic pain? In this Coffee Break Webinar, Dr Yang Yang (Purdue University) discusses advances in the treatment of Inherited Erythromelalgia (IEM) using a pharmacogenomic approach. IEM, also known as “Man on Fire” syndrome, is a chronic pain syndrome characterized by burning pain in the hands and feet. The chronic pain of most patients with IEM cannot be relieved by common pain killers making this disease a major unmet medical need.
The drug responsiveness of different genetic mutations associated with IEM were probed in an in vitro Maestro MEA assay, with the results helping to predict the effective treatment of these IEM patients in the clinic. This precision medicine approach, guided by genomic analysis and functional profiling, provides a promising new way to extinguish the fire of the burning man.