Fleck D, Phu L, Verschueren E, Hinkle T, Reichelt M, Bhangale T, Haley B, Wang Y, Graham R, Kirkpatrick DS, Sheng M, Bingol B.
Journal of Neuroscience, 2019
Summary:
PTCD1 was identified as an Alzheimer's target using whole-exome sequencing data of 4549 cases with 3332 age-matched controls. The role of PTCD1 in mitochondrial function and synaptic activity of neurons is investigated.
Keywords: Alzheimer's disease, AD, neurodegeneration, whole-exome sequencing, PTCD1, mitochondrial dysfunction, oxidative phosphorylation, metabolism
