McConnell ER, McClain MA, Ross J, Lefew WR, Shafer TJ.
Neurotoxicology, 2012
Summary:
Multiwell microelectrode array (MEA) systems were used to evaluate 30 chemicals on the spontaneous activity in networks of cortical neurons. Recordings in the multi-well MEA plates showed positive mean network spike rate for twenty positive (known evoked activity) drugs highlighting the high sensitivity and specificity of the assay.
Keywords: neurons, multi-well MEA (mwMEA), neurotoxicity, safety, EPA, neurotoxicology, screening
Evaluation of multi-well microelectrode arrays for neurotoxicity screening using a chemical training set
